Tangential Flow Filtration Market Size - By Product Type (Systems {Single-use, Reusable}, Membrane, Accessories), Technology (Microfiltration), Application (Protein Purification), End-use (Pharma & Biotech Companies), Global Forecast, 2023 - 2032

Tangential Flow Filtration Market Size

Tangential Flow Filtration Market size accounted for USD 1.8 billion in 2022 and is estimated to grow at 11.8% to reach USD 5.5 billion by till 2032. The rising prevalence of chronic diseases along with increasing focus on precision medicine & personalized therapies options have accelerated the demand for biopharmaceuticals.
 

Also, the increasing investment by pharmaceutical & biotechnological companies in TFF technology is anticipated to boost the industry gains. Moreover, the increasing outsourcing of biopharmaceutical manufacturing to contract manufacturing organizations (CMOs) that utilize TFF systems for large-scale production.
 

Tangential flow filtration (TFF), also known as crossflow filtration, is a separation technique used in biopharmaceutical and industrial applications to separate and purify biomolecules from complex mixtures. TFF is commonly used for concentration, purification, and size-based separation of proteins, antibodies, vaccines, gene therapy, and other biopharmaceutical products.
 

COVID-19 Impact

The COVID-19 pandemic had a positive impact on the tangential flow filtration market. With the urgent need for vaccine development and the production of therapeutic antibodies and viral vectors, TFF technology has played a pivotal role in enabling efficient downstream processing and purification of biopharmaceutical products. Moreover, the increased focus on bioprocess optimization and stringent quality requirements during the pandemic has further emphasized the value of tangential flow filtration as a critical tool for delivering high-quality and effective biologics.
 

Tangential Flow Filtration Market Trends

The increasing adoption of single-use bioprocessing systems in biopharmaceutical manufacturing is expected to spur the industry expansion. These systems offer several advantages that streamline bioprocessing workflows and enhance product quality. Also, by eliminating the need for complex cleaning and validation procedures between processes, single-use TFF systems reduce downtime and improve operational efficiency. Moreover, their ability to minimize the risk of cross-contamination ensures product purity and safety, meeting the stringent regulatory standards. Further, single-use TFF systems provide scalability and cost-effectiveness, making them an attractive option for both small-scale research and large-scale commercial production.
 

Tangential Flow Filtration Restraint

High initial investment required for the implementation of tangential flow filtration may hamper the market tangential flow filtration progress. Incorporating TFF technology into biopharmaceutical and industrial processes demands significant financial resources for procuring sophisticated equipment, specialized membranes, and ancillary components. Also, training skilled personnel to operate and maintain the TFF systems adds to the overall cost. This substantial upfront investment poses a challenge, particularly for small and medium-sized enterprises to adopt TFF technology on a large scale.
 

Tangential Flow Filtration Market Analysis

By product type, the tangential flow filtration market is classified into systems, membrane filters, and accessories. The systems segment accounted for 52% of the market share in 2022. Increasing prevalence of chronic diseases such as cancer, diabetes, and cardiovascular conditions. For instance, according to the International Diabetes Federation report, in 2021, approximately 537 million adults (20-79 years) are living with diabetes. As the global burden of chronic illnesses rises, there is a growing demand for advanced biopharmaceutical products and therapies to effectively address these health challenges.
 

Based on technology, the tangential flow filtration market is segmented into microfiltration, ultrafiltration, nanofiltration, and other technologies. The microfiltration segment accounted for 45.7% of the market share in 2022. The integration of microfiltration in TFF systems allows effective clarification of solutions and separation of particulate matter, thereby minimizing clogging and ensuring smooth filtration processes. Also, microfiltration's gentle filtration mechanism preserves the integrity of sensitive biomolecules during the purification process, leading to higher product yields and minimizing product loss.
 

Based on application, the tangential flow filtration market is segmented into protein purification, vaccine and viral vectors, antibody purification, raw material filtration, and other applications. The protein purification segment is projected to witness considerable development of 11.5% by 2032. Increasing complexity of biopharmaceutical products and the rising demand for novel protein-based therapeutics is expected to supplement the segmental evolution. The integration of advanced automation features in TFF systems streamlines the filtration process by lowering the need for manual intervention and minimizing the chance of human error.
 

Based on end-use, the tangential flow filtration market is segmented into pharmaceutical & biotechnology companies, contract research organizations & contract manufacturing organizations, and academic institutes & research laboratories. The pharmaceutical & biotechnology companies segment is projected to witness considerable growth of 11.8% over the analysis timeframe. Moreover, increasing investment in research and development activities by biopharmaceutical companies to discover new therapies and treatments.
 

North America tangential flow filtration market accounted for 44.3% industry share in 2022. The presence of numerous prominent pharmaceutical and biotechnology companies that are actively engaged in developing innovative biologics and advanced therapies in the region. Also, presence of well-established TFF technology providers, along with the increasing adoption of advanced technologies.
 

Tangential Flow Filtration Market Share

Major market players operating in the tangential flow filtration market include

• REPLIGEN CORPORATION
• ABEC, INC.
• Merck KGaA
• Sterlitech Corporation 
• Synder Filtration, Inc.

Tangential Flow Filtration Industry News:

• In September 2021, ABEC launched its custom single run (CSR) tangential flow filtration (TFF) systems to increase downstream productivity for its bioprocess customers. This strategy helped the company to enhance its product offering and drive revenue growth.
   
• In April 2020, Sartorius acquired part of Danaher’s life sciences business that included chromatography hardware, industrial skids, resins, and single-use tangential flow filtration (TFF) systems. This strategy helped the company to expand its product offering and customer base.
   

The tangential flow filtration market research report includes an in-depth coverage of the industry with estimates & forecast in terms of revenue in USD from 2018 to 2032, for the following segments:

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By Product type

• Systems
  • Single-use tangential flow filtration systems
  • Reusable tangential flow filtration systems
• Membrane Filters
  • Polyethersulfone (PES)
  • Polyvinylidene difluoride (PVDF)
  • Regenerated cellulose
  • Polytetrafluoroethylene (PTFE)
  • Polycarbonate tracked etched (PCTE)
  • Mixed cellulose ester & cellulose acetate
  • Other membrane filters
• Accessories

By Technology

• Microfiltration
• Ultrafiltration
• Nanofiltration
• Other technologies

By Application

• Protein purification
• Vaccine and viral vectors
• Antibody purification
• Raw material filtration
• Other applications

By End-use

• Pharmaceutical & biotechnology companies
• Contract research organizations & contract manufacturing organizations
• Academic institutes & research laboratories

The above information is provided for the following regions and countries:

• North America
  • U.S.
  • Canada
• Europe
  • Germany
  • UK
  • France
  • Spain
  • Italy
  • Rest of Europe
• Asia Pacific
  • Japan
  • China
  • India
  • Australia
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East & Africa
  • South Africa
  • Saudi Arabia
  • Rest of Middle East & Africa