Reconstructed Skin Models Market – Type (Reconstructed Human Epidermis, Reconstructed Human Skin), Application (Skin Irritation, Corrosion, Sensitization, Biopsy, Radioallergosorbent, & Pigmentation Test), End User, Global Forecast (2024 – 2032)

Reconstructed skin models Market Size

Reconstructed Skin Models Market size was valued at USD 37.1 Million in 2023 and is anticipated to showcase growth at 14.6% CAGR from 2024 – 2032, owing to rising adoption of alternative testing procedures to animal testing, increasing prevalence of skin disorders, and growing focus on precision cosmetic products.
 

Additionally, growing investments in the development of advanced in-vitro models is also supporting the market growth. The growing investments reflect a paradigm shift towards a more predictive and cost-effective, approaches for safety assessment and biomedical research. Reconstructed skin models generally refer to in-vitro replicas of human skin, designed to simulate the structure, function, and physiological reactions of natural human skin. These models are utilized across various scientific disciplines, such as dermatology, cosmetics, pharmacology, toxicology, and regenerative medicine, for study skin-related phenomena.
 

Reconstructed Skin Models Market Trends

• Advances in tissue engineering, biomaterials, organs-on-a-chips, and 3D bioprinting are improving the development of biologically accurate reconstructed skin models driving their adoption across various testing environments. For instance, the living human skin-on-a-chip model replicates blood vessels, mimicking the human skin microenvironment closely. These models simulate microvasculature for real-time analysis of transdermal drug delivery.
   
• Growing use of reconstructed skin models in disease modeling and drug discovery is also expected to contribute to the market growth during the forecast period. Reconstructed skin models are gaining traction in disease modeling, particularly in dermatological research, as they can efficiently replicate the pathophysiology of skin conditions like psoriasis, eczema, and skin cancer, thus providing an alternative to animal testing models.
   

Reconstructed Skin Models Market Analysis

Based on type, the market is segmented into reconstructed human epidermis and reconstructed human skin. The reconstructed human epidermis segment held the majority of market share in 2023 and is anticipated to grow at CAGR of 14.4% over the coming years.
 

• The majority share of the reconstructed human epidermis segment can be attributed to their growing use in barrier function studies and permeation assays performed during safety testing of cosmetic and personal care products. The reconstructed human epidermis enables the examination of the potential for irritation, sensitization, and phototoxicity caused by cosmetic ingredients and formulations, offering important information for product safety labeling and compliance with regulations.
   
• Furthermore, reconstructed human epidermis models are also finding growing use in optimizing the drug delivery systems. These models serve as a valuable tool for examining the absorption and permeation of topical medications, including ointments, creams, and transdermal patches. As a result, their adoption across pharmaceutical companies and personal care product manufacturers has increased, which is further driving the market growth.
   

Based on application, the reconstructed skin models market is classified into skin irritation test, skin corrosion test, skin sensitization test, skin biopsy, radioallergosorbent test, skin pigmentation test, and other applications. The skin irritation test segment dominated the market with a revenue of about USD 9.73 Million in 2023.
 

• Growing approvals from regulatory authorities such as EU for reconstructed skin model-based skin irritation test as an alternative to in vivo (rabbit) skin irritation test is driving the revenue growth in skin irritation test segment.
   
• Moreover, skin irritation tests are considered mandatory by chemical regulation authorities for chemical companies. Chemical companies are required to develop product hazard labeling and assess risks for exposure to skin- and eye-irritating chemicals. As a result, chemical companies find significant use of skin irritation test that are conducted over reconstructed skin models globally.
   
• Growing awareness towards using safe skin care and cosmetic products and with growing demand for ingredient transparency, companies are facing pressure to guarantee the safety of their products. Skin irritation test are enabling the early detection of potentially harmful ingredients and formulations during product development, which is minimizing the chances of adverse reactions and safeguarding consumer health, thereby driving the adoption of skin irritation test globally.
   

Based on end user, the reconstructed skin models market is classified into cosmetics and cosmeceutical companies, chemical companies, and other end users. The cosmetics and cosmeceutical companies segment secured a share of about 62.5% in 2023 and is anticipated to grow at 14.8% CAGR during the forecast period.
 

• Increasing growth in cosmetic and cosmeceutical production is fueling the demand for ensuring product safety and efficacy, thereby driving the demand for reconstructed skin models in the cosmetic and cosmeceutical companies segment.
   
• According to the Environmental Working Group (EWG), during 2009-2020, about 595 cosmetic manufacturers reported using 88 chemicals across more than 73,000 products that were linked to cause cancer and other disorders. As a result, the demand for ensuring safety of cosmetic products using reconstructed skin models has increased globally, which is contributing to the market growth.
   
• Moreover, growth in geriatric population is driving the adoption of anti-aging cosmetic products, which has further increased the demand for skin irritation test, and skin corrosion test across cosmetic and cosmeceutical companies, thereby contributing to the increasing demand for reconstructed skin models.

In 2023, Europe reconstructed skin models market accounted for 37.4% of market share in global market and is predicted to reach USD 44.9 Million by 2032.
 

• Europe is a leading manufacturer of cosmetic and cosmeceutical products owing to the presence of established players in the region. According to Cosmetic Europe, cosmetic manufacturers are spending about 5% of their annual revenue on R&D. As a result, a significant share of revenue is spent on safety and efficacy testing of products, which is contributing to an increasing demand for reconstructed skin models in the region.
   
• European governments and regulatory bodies are promoting the development and implementation of alternative testing methods such as reconstructed skin models, to promote animal welfare and scientific innovation. Initiatives such as The European Partnership for Alternative Approaches to Animal Testing (EPAA) and the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) are encouraging the use of reconstructed skin models, offering guidance on validation and regulatory acceptance.
   
• Presence of wealth of research institutions and academic centers that specialize in tissue engineering, biomaterials, and in-vitro testing technologies such as University of Manchester, and Lyonbiopôle are contributing to the advancement and commercialization of reconstructed skin models, driving innovation and market growth in the region.
   

Germany reconstructed skin models market was valued at USD 3.4 Million in 2023 and is anticipated to grow at a CAGR of 14.1% over the forecast period.
 

• High incidence of skin related disorders in Germany are driving the adoption of skin care products, which is rising the demand for safety and efficacy testing, thereby contributing to the revenue growth in market in the country. For instance, according to April 2022 study published by The Deutsche Dermatologische Gesellschaft (German Dermatological Society), about 30-70% of people in Germany are affected with at least one skin disease in their lifetime.
   
• The dominating share of Germany can be attributed to the presence of stringent government regulations governing the safety and efficacy testing of cosmetics, skin care, and chemical products. To comply with regulations such as the Cosmetics Regulation (Regulation (EC) No 1223/2009) and the European Union's REACH regulation necessitates comprehensive safety assessments, including skin sensitization and irritation testing. As a result, the demand for reconstructed skin models is increasing in the country.
   
• Growing awareness towards alternative methods to animal testing in the country is also driving the adoption of reconstructed skin models among end user.
   

The U.S. reconstructed skin models market is expected to show significant growth during the forecast period.
 

• Regulatory shift towards using alternative methods to animal testing for product safety assessment is driving the demand for reconstructed skin models. Agencies such as the U.S. Food and Drug Administration (FDA) and the Environmental Protection Agency (EPA) are encouraging the use of in-vitro models, including reconstructed skin models, as reliable alternatives to traditional animal testing methods in the U.S.
   
• Leveraging an ongoing advancement in tissue engineering and in-vitro testing technologies in the country vendors are focusing towards developing a more sophisticated and physiologically relevant reconstructed skin models. This has led to an easy availability of advanced products in the market, driving their adoption in the country.
   

India reconstructed skin models market is anticipated to grow remarkably over the coming years.

• Increasing incidence of skin diseases such as acne and atopic dermatitis is driving the use of skin care and cosmeceutical products thereby increasing the adoption of reconstructed skin models across cosmetic and cosmeceutical companies. According to a 2023 study published by Indian Journal of Dermatology, the prevalence of skin diseases such as atopic dermatitis is increasing owing to changes in environmental factors. This is contributing to an increasing growth in the market.
   
• India is also one of the major producer of chemical products. According to the February 2024 statistics from Indian Brand Equity Foundation, India was worlds sixth largest chemical producer. Owing to the presence of large number of chemical manufacturing companies, the demand for safety profiling of chemicals is high across chemical manufacturers, which is driving the adoption of reconstructed skin models across chemical companies in India.
   

Reconstructed Skin Models Market Share

The reconstructed skin models industry is moderately fragmented due to the presence of established, medium-scale and small vendors. Established vendors mainly rely on their scale and investments. Product launches and collaborations are among the key strategic initiatives considered by established players to gain competitive edge in the market. Small scale vendors rely on low pricing strategies to compete with established players.
 

Reconstructed Skin Models Market Companies

Prominent players operating in the reconstructed skin models industry include:

• AIVITA Biomedical, Inc.
• BICO - THE BIO CONVERGENCE COMPANY
• CELLnTEC
• EPISKIN
• Henkel AG & Co. KGaA
• Japan Tissue Engineering Co., Ltd.
• Mallinckrodt plc
• STRATICELL
• WEPREDIC Group (Biopredic International)
• ZenBio, Inc.
   

Reconstructed Skin Models Industry News:

In August 2023, EPISKIN launched The SkinEthic HBE (Human Bladder Epithelium), a new epithelium model at 12th World Congress on Alternatives and Animal Use in Life Sciences.
 

• In September 2023, Mallinckrodt plc announced to receive the US FDA approval for administration label update for StrataGraft, an allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen, thereby reducing the requirements for Xenotransplantation.
   

The reconstructed skin models market research report includes an in-depth coverage of the industry with estimates & forecast in terms of revenue in USD Million from 2021 - 2032 for the following segments:

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Market, By Type

• Reconstructed human epidermis
• Reconstructed human skin

Market, By Application

• Skin irritation test
• Skin corrosion test
• Skin sensitization test
• Skin biopsy
• Radioallergosorbent test
• Skin pigmentation test
• Other applications

Market, By End-user

• Cosmetics and cosmeceutical companies
• Chemical companies
• Other end-users

The above information is provided for the following regions and countries:

• North America
  • U.S.
  • Canada
• Europe
  • Germany
  • UK
  • France
  • Spain
  • Italy
  • Netherlands
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • Australia
  • South Korea
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East and Africa
  • South Africa
  • Saudi Arabia
  • UAE
  • Rest of Middle East and Africa