Protein Purification & Isolation Market - Technology [Preparative Chromatography, (Affinity, Ion Exchange), Ultrafiltration], Product [Consumable (Kit, Reagent), Instrument], Application (Protein-Protein Interaction), End-user, Global Forecast 2023-2032

Protein Purification & Isolation Market Size

Protein Purification & Isolation Market size was valued at USD 8.3 Billion in 2022 and is expected to reach USD 22.4 Billion in 2032 with CAGR of 10.5%. The growth is majorly attributed to factors such as increasing research and development in pharmaceutical and biotechnology companies, rising demand for biologics, and technological advancements in protein purification and isolation techniques.
 

Protein purification refers to a process of isolating a specific protein or a group of proteins from a complex mixture of biological components. The protein purification & isolation facilitates in obtaining the target protein in a highly purified and biochemically active form. This process is essential for studying the structure, function, interactions, and potential applications of protein in research, diagnostics, and therapeutics.
 

COVID-19 Impact

The pandemic significantly disrupted the supply chain that resulted in delayed delivery of manufacturing the essential required for protein purification and isolation including protein purification and isolation kits, reagents, and other consumables. The shortage of such products impacted the growth of protein purification and isolation market. The lockdown and travel restrictions led to temporary closure or reduced the capacity in research laboratories and institutes, hindering the growth of the protein purification & isolation market.
 

Later as the COVID cases decreased the manufacturing of consumables were back to routine and the academic and research institutes were opened and resumed their ongoing research activities. The demand for protein purification and isolation procedures increased due to the increasing research and development by the pharmaceutical industries and increasing demand for biologics.
 

Protein Purification & Isolation Market Driving & Restraining Factors

The increasing research and development in pharmaceutical and biotechnology companies, rising demand for biologics, technological advancements in protein purification and isolation techniques, and rise in the prominence of contract research organizations (CROs) are the major factors driving the growth of this market. The biotechnology and pharmaceutical companies are focusing on research and development of biologics and other protein-based therapeutics which increases the demand for purified proteins. Protein isolation and purification is a crucial step in drug development to study the structure and function of the proteins. As a result, the demand for protein purification and isolation is expected to increase with the increasing prevalence of chronic diseases and rising demand for novel treatment options.
 

The factors such as high cost of purification instruments and lack of skilled technicians are expected to restrain the growth of the global protein purification and isolation market. The high upfront cost of the most advanced purification instruments, including high-performance chromatography systems, centrifuges, and automated workstations, can be a barrier for research labs, particularly smaller academic institutions or startups with lower budgets. For protein purification and isolation techniques a deep understanding of both the theoretical principles and practical execution is required. Lack of skilled technicians can lead to lower yield, in adequate process, and increased risk of errors.
 

Protein Purification & Isolation Market Analysis

Based on technology, the protein purification & isolation market is divided into preparative chromatography, ultrafiltration, precipitation, electrophoresis, western blotting, dialysis & diafiltration, and centrifugation. Among the technologies, preparative chromatography segment dominated the global market with market share of 29.5% in 2022. This technology allows selective capture and purification of target proteins based on specific interactions and helps to obtain purified protein with minimal interference from other molecules. For research and therapeutic proteins needs to be in highly pure form. This technology facilitates in achieving high levels of purity by effectively separating the target protein from contaminants and impurities. Due to its ability to provide high purity, selectivity, scalability, and reproducibility it offers a robust and efficient approach for obtaining purified proteins.

Based on product, the global protein purification & isolation market is segmented into consumables and instruments. The consumables segment is sub-segmented into protein purification kits, reagents, prepared columns, protein purification resins, magnetic beads, and other consumables. The magnetic beads segment is further sub-segmented into tagged magnetic beads and non-tagged magnetic beads.

In 2022, the consumables segment accounted for highest business share of 62.9%. Consumables such as kits, reagents, columns, resins are essential for performing chromatography techniques to purify and isolate proteins. Among the consumables segment, the protein purification kits accounted for highest market share as it simplifies the workflow, reduces the risk of cross-contamination, and enhances process efficiency. These kits are valuable in high-throughput processes or when working with multiple samples simultaneously.
 

Based on application, the global protein purification & isolation market is categorized into protein-protein interaction studies, drug screening, biomarker discovery, target identification, disease diagnostics & monitoring, and protein therapeutics. The protein-protein interaction studies held a significant share in 2022 and is expected to grow with a CGAR of 10.6% during the forecast period. The protein purification provides a controlled environment for studying protein-protein interaction. It enables accurate characterization of binding affinities and kinetics. The increasing adoption of this technique for obtaining highly purified proteins and increasing research studies related to structural protein are driving the growth of this segment.

Based on end-user, the protein purification & isolation market is classified into academic medical institutes, pharmaceutical & biotechnology companies, hospitals & diagnostics centers, and contract research organizations (CROs). The academic medical institutes accounted for highest market share in 2022 and is expected to reach USD 3.4 billion. The academic institutes are hubs for fundamental scientific research. The protein purification and isolation are essential process for such research institutes for understanding the structure, function, and interactions of proteins, that underlies different biological processes. During the forecast period, the contract research organizations are expected to witness growth at highest CAGR as CROs conduct precise research and development for pharmaceutical companies and increasing number of preclinical trials for drug development outsourced by the companies.

The north American protein purification and isolation market is expected to grow at CAGR of 10.3% over the forecast timeframe. North America has highly advance research and academic institutes which heavily rely on protein purification and isolation techniques. Addition this region has robust biotechnology and pharmaceutical industry which increases the demand for protein purification and isolation. Moreover, the supportive regulatory agencies, strong research, and academic institutes, increasing number of CROs, increasing demand for biologics and increasing clinical trials and drug development are collectively contributing to the growth of this market.
 

Protein Purification & Isolation Market Share

The key players in the protein purification & isolation market are

• Thermo Fisher Scientific Inc.
• Merck & Co. Inc.
• QIAGEN NV
• Bio-Rad Laboratories, Inc.
• Agilent Technologies, Inc.
• Promega Corporation
• Danaher Corporation
• Norgen Biotek Corp.
• Abcam plc
• Purolite

These companies are implementing several strategies such as collaborations, acquisitions, partnerships, mergers, and product launches to maintain a competitive edge in the industry.

Protein Purification & Isolation Industry News:

• In August 2021, Danaher Corporation acquired Aldevron. Aldevron is now operating as a standalone company and brand within Danaher’s Life Science segment. This acquisition has helped enhance their product portfolio and grow their market cap.
   
• In March 2021, Promega Corporation launched XpressAmp direct amplification reagents. This strategic initiative helped the company to strengthen their product portfolio and boost the revenue of the company.
   

The global protein purification & isolation market research report includes an in-depth coverage of the industry with estimates & forecast in terms of revenue in USD Million from 2018 to 2032 for the following segments:

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Market Size, By Technology

• Preparative chromatography
  • Affinity chromatography
  • Ion exchange chromatography
    • Immobilized metal ion affinity chromatography (IMAC)
    • Immunoaffinity chromatography (IAC)
    • Bead-based chromatography
  • Reverse-phase chromatography
  • Hydrophobic charge induction chromatography
  • Size exclusion chromatography
• Ultrafiltration
• Precipitation
• Electrophoresis
  • Gel electrophoresis
  • Isoelectric focusing electrophoresis
  • Capillary electrophoresis
• Western blotting
• Dialysis & diafiltration
• Centrifugation

Market Size, By Product

• Consumables
  • Protein purification kits
  • Reagents
  • Prepared columns
  • Protein purification resins
  • Magnetic beads
    • Tagged magnetic beads
    •  Non-tagged magnetic beads
• Instruments

Market Size, By Application

• Protein-protein interaction studies
• Drug screening
• Biomarker discovery
• Target identification
• Disease diagnostics & monitoring
• Protein therapeutics

Market Size, By End-user

• Academic medical institutes
• Pharmaceutical & biotechnology companies
• Hospitals & diagnostics centers
• Contract research organizations

The above information is provided for the following regions and countries:

• North America
  • U.S.
  • Canada
• Europe
  • Germany
  • UK
  • France
  • Spain
  • Italy
  • Switzerland
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • Australia
  • South Korea
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East & Africa
  • South Africa
  • Saudi Arabia
  • Rest of Middle East & Africa