Nucleotides Market Size

Nucleotides Market in 2022 was valued at USD 588.4 million and is anticipated to USD 1.1 billion by 2032. The significant factors driving the growth of this market includes rising demand for nucleotide-based therapeutics and increased research in genomics and molecular biology.

Therapeutics comprising of nucleotide entities is broad class, encompassing nucleotide analog, oligonucleotides, and nucleic acid-based treatments. Nucleotide and nucleoside-based medications have undergone extensive exploration, leading to the approval of clinical candidates for various applications such as antiviral, anticancer, antibacterial, and antirheumatic treatments, thereby significantly influencing the growth of this market.

Nucleotides are organic molecules that serve as the basic building blocks of nucleic acids, including DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). These molecules play a crucial role in various biological processes, such as genetic information transfer, cellular energy transfer, and enzymatic reactions. Also, nucleotides are used in drug development, genetic research, diagnostics, and other molecular biology applications.

COVID-19 Impact

The need for widespread COVID-19 testing during the pandemic has highlighted the importance of diagnostics in managing and controlling the spread of infectious diseases. Nucleotide-based tests, such as PCR technologies, are fundamental for detecting the presence of the virus. This increased emphasis on diagnostics have positively impacted the demand for nucleotides used in these tests. Further, nucleotides are essential in vaccine development processes, including the production of mRNA vaccines. In addition to this, the success of mRNA vaccine technologies, such as those developed by Pfizer-BioNTech and Moderna, has emphasized the potential of nucleotide-based approaches in vaccine development.

Nucleotides Market Trends

• The development of nucleotide-based therapeutics, including antisense oligonucleotides and RNA-based therapies, has gained momentum. Nucleotides play a crucial role in these therapeutic approaches, and the market has seen increased investment in drug development.
  
• Nucleotide-based therapeutics are particularly well-suited for treating genetic and rare diseases. The ability to specifically target the underlying genetic causes of these conditions makes nucleotide-based approaches highly valuable.
  
• Also, increased research in genomics and molecular biology is a major driver behind the growth of the market. Genomics, the study of entire genomes, and molecular biology, the study of biological molecules and their interactions within cells, heavily rely on nucleotides. Such aforementioned factors is expected to spur the market growth during the analysis period.
  

Nucleotides Market Analysis

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Based on nitrogenous base, the global market is segmented into purine and pyrimidine. The purines segment accounted for majority of buiness share in 2022.

• Purine derivatives are often used in pharmaceuticals and therapeutic applications. For example, purine-based drugs may be used to treat conditions such as gout multiple sclerosis, as well as certain cancers and viral infections.
  
• Similarly, purines are widely used in molecular biology research, genetic engineering, and biotechnology. They serve as building blocks for DNA synthesis in various applications, including PCR (polymerase chain reaction) and DNA sequencing.
  
• Therefore, the increasing demand for nucleotides in the pharmaceutical industry as well as in research application may contribute to a higher market share for purines segment.
  

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Based on application, the nucleotides market is classified into diagnostics research, pharmaceuticals, and other applications. In 2022, diagnostics research segment dominated the market and was valued at USD 382.4 million.

• Nucleotides play a fundamental role in numerous molecular diagnostics techniques, facilitating precise detection, analysis, and comprehension of genetic material across diverse diagnostic applications. Also, ongoing advancements in nucleotide-based technologies persistently propel the utilization of these technologies in the domain of diagnostics research. Thus, with a rising need for precise and sensitive diagnostics, it is anticipated that the market for nucleotides employed in diagnostic applications will experience significant growth.
  

Based on technology, the nucleotides market is categorized into TaqMan allelic discrimination, SNP by pyrosequencing, gene chips & microarrays, and other technologies. The TaqMan allelic discrimination segment is anticipated to grow at 5.9% between 2023 to 2032 period.

• TaqMan allelic discrimination assays is a real-time PCR-based method known for their high accuracy and sensitivity. In this technology, nucleotides are used as part of the PCR reaction mix. These nucleotides are incorporated into the growing DNA chain by a DNA polymerase during the extension step.
  
• TaqMan allelic discrimination is versatile and can be applied to various research areas, including human genetics, pharmacogenomics, and infectious disease research. Its broad applicability across different fields contributes to its widespread adoption.
  

Based on product, the nucleotides market is divided into deoxynucleotides, ribonucleotides, labelled nucleotides, and dideoxy nucleotides. The deoxynucleotides segment held is expected to reach USD 527.6 million by 2032.

• Deoxynucleotides are essential building blocks for DNA synthesis. They serve as the monomeric units that polymerize to form the DNA backbone during replication. Thus, increasing need for accurate and efficient DNA synthesis propels the growth of this segment.
  
• Deoxynucleotides are critical in DNA replication and amplification processes. Techniques like polymerase chain reaction (PCR), a widely used method in molecular biology, rely on deoxynucleotides for the amplification of specific DNA sequences. Thus, increasing utilization of deoxynucleotides is expected to augment the segment expansion.
  

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The North America nucleotides market is anticipated to witness growth at 5.5% during the analysis period to reach USD 420.2 million by 2032.

• North America, particularly the U.S., is epicenter to few of the world's leading biotechnology and pharmaceutical companies. The region has a robust research and development infrastructure, which contributes to the demand for nucleotides in various applications, including drug development, diagnostics, and genetic research.
  
• Also, the region has well-established healthcare systems and is often an early adopter of advanced diagnostic technologies. Therefore, adoption of nucleotides in molecular diagnostics, and the region's emphasis on cutting-edge healthcare solutions contributes to a higher market share for nucleotides.
  

Nucleotides Market Share

The nucleotides industry is characterized by the presence of several key players adopting technological advancements, research and development activities, and strategic initiatives:Thermo Fisher Scientific Inc., F. Hoffmann-La Roche Ltd., and Agilent Technologies account for significant market share in the overall nucleotides market. They employ nucleotides in several applications such as pharmaceuticals, diagnostics, and biotechnology.

Market players operating in the nucleotides market are as mentioned below:

• Nanjing Bio Together Co., Ltd.
• Agilent Technologies
• F. Hoffmann-La Roche Ltd. (CustomBiotech)
• CJ CHEILJEDANG CORP.
• DAESANG
• Jena Bioscience GmbH
• MEIHUA HOLDINGS GROUP CO. LTD
• Promega Corporation
• STAR LAKE BIOSCIENCE
• Thermo Fisher Scientific Inc.
  

Nucleotides Industry News:

• In February 2019, Thermo Fisher Scientific Inc. signed a multi-year agreement with Mainz, Germany-based BioNTech ensuring the consistent supply of nucleotides, enzymes and other critical raw materials for messenger RNA (mRNA) vaccine manufacturing. This agreement enabled company to boost their revenue and increase their customer base.
  
• In April 2018, Agilent Technologies acquired Lasergen, Inc, a company expertise in nucleotide chemistry and next-generation sequencing. This strategic acquisition has helped the company to reach untapped potential market and increase the revenue.
  

The nucleotides market research report includes an in-depth coverage of the industry with estimates & forecast in terms of revenue in USD Million from 2018 to 2032 for the following segments:

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By Nitrogenous Base, 2018 – 2032 (USD Million)

• Purine
• Pyrimidine

By Application, 2018 – 2032 (USD Million)

• Diagnostics research
• Pharmaceuticals
• Other applications

By Technology, 2018 – 2032 (USD Million)

• TaqMan allelic discrimination
• SNP by pyrosequencing
• Gene chips & microarrays
• Other technologies

By Product, 2018 – 2032 (USD Million)

• Deoxynucleotides
• Ribonucleotides
• Labelled nucleotides
• Dideoxy nucleotides

The above information is provided for the following regions and countries:

• North America
  • U.S.
  • Canada 
• Europe
  • Germany
  • UK
  • France
  • Spain
  • Italy
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • Australia
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East & Africa
  • South Africa
  • Saudi Arabia
  • Rest of Middle East & Africa