Lyophilization Equipment Market

Lyophilization Equipment Market Size

The global lyophilization equipment market was valued at USD 7 billion in 2024. The market is expected to reach from USD 7.5 billion in 2025 to USD 16.1 billion in 2034, growing at a CAGR of 8.8% during the forecast period. Lyophilization equipment denotes devices used in the process of lyophilization which involves freeze drying. This equipment works by withdrawing moisture from the products such as drugs, biological as well as food material by freezing followed by primary drying (sublimation), and secondary drying (desorption).

The growth of the global lyophilization equipment market is highly attributed due to the rising prevalence of chronic conditions such as cancer, diabetes, and cardiovascular diseases, which is a key catalyst that is accelerating market growth. For instance, according to the data from the World Health Organization (WHO), in 2022, around 20 million people globally were diagnosed with cancer and 9.7 million deaths were reported. Moreover, as per the 2022 report of Global Cancer Observatory, lung cancer was the most common type of cancer worldwide with 2.5 million cases followed by breast cancer with 2.3 million cases, then colorectal cancer with 1.9 million cases, prostate cancer with 1.5 million cases, and stomach cancer with 970,000 cases.

Thus, these conditions required long term treatment inclusive of vaccines, biologics, and other sensitive pharmaceutical with enhanced stable and extended shelf life. Lyophilization equipment plays a significant role in preserving the efficacy and stability of such therapeutics by removing the moisture content without any effect on the product stability and integrity. Therefore, as the prevalence of chronic disease conditions increases, so does the demand for these therapeutics, which in turn necessities the need for lyophilization equipment in order to ensure the product safety and long-term storage of the therapeutical products, fostering market growth.

Moreover, the increasing global need for freeze dryers substantiates its significance in the biopharmaceutical sector, along with the growing emphasis on pharmaceutical and food industries coupled with the increasing manufacturer's focus on developing products with longer stability.

Lyophilization Equipment Market Trends

• Technological advancements in lyophilization techniques and associated products is one of the major accelerator for the growth of the market.
  
• For instance, Lyoguard trays, a remarkable modern invention, play an important role in the handling of sensitive items during freeze-drying. These trays help ensure uniform moisture removal by promoting even temperature distribution, resulting in consistent lyophilization across samples. This uniformity is particularly important in the pharmaceutical and biopharmaceutical industries, where maintaining product integrity is essential.
  
• A notable example of this trend is the GORE Lyoguard Freeze-Drying Trays, which utilizes ePTFE membrane technology to effectively protect liquid, or lyophilized active pharmaceutical ingredients (APIs) during the process. Their combination of advanced materials, enhanced structural durability, and improved thermal conductivity help to minimize the risk of contamination and optimize drying conditions.
  
• Moreover, the rapid growth of the pharmaceutical is stimulating the demand for lyophilization equipment. The growing need for stable formulations of biologics, vaccines, and injectables is pushing companies to invest in advanced freeze-drying solutions.
  
• Together, these trends are creating strong, sustained demand across multiple sectors, thereby fostering market growth in the forward direction
  

Trump Administration Tariffs

• Tariffs on Chinese imports, including essential components such as stainless-steel parts, control panels, refrigeration units, and vacuum systems many of which are crucial for lyophilization equipment are anticipated to raise production costs across the global market.
  
• A significant number of manufacturers currently depend on China for cost-efficient sourcing of these critical parts. With the imposition of tariffs, supply chains could be disrupted, resulting in elevated manufacturing expenses and logistical bottlenecks.
  
• Therefore, companies in the lyophilization equipment market are expected to reassess their sourcing strategies and reduce over reliance on Chinese imports. This is likely to encourage a gradual transition toward alternative procurement and manufacturing locations such as India, Vietnam, Mexico, and Eastern European countries, where trade risks are comparatively lower and operational costs remain favourable.
  
• However, in the near term, these strategic shifts may lead to challenges such as project delays and added expenses during vendor onboarding. Additionally, companies may face temporary disruptions in the integration and servicing of critical subsystems, including temperature control modules and automated interface systems.
  

Lyophilization Equipment Market Analysis

Based on product, the market is segmented into devices and consumables. The devices segment is bifurcated into tray-style freeze dryers, manifold freeze dryers, and rotary freeze dryers. Further, the consumables segment is segmented into lyoguard trays, manifolds and vial holders/adapters, vacuum pumps, product sensors and temperature probes, pouches, and other consumables. The global market was estimated at USD 7 billion in 2024.The devices segment dominated the market with the largest revenue of USD 3.7 billion in 2024 and is expected to grow at a significant CAGR over the forecast period.

• The growth of the segment is highly attributed due to the rising demand of automated, high-throughput, and energy efficient freeze dryers, particularly rotary freeze dryers and tray style dryers, which are predominantly used in the large-scale production of the heat sensitive products such as the biologics, vaccines, and diagnostic reagents.
  
• Moreover, the ongoing advancement in the lyophilization devices and improvement in the device features such as real time monitoring capabilities, system integration and better control on the crucial parameters such as temperature and vacuum are further fostering the adoption of these advanced lyophilization devices in the pharmaceutical and biopharmaceutical sectors.
  
• For instance, Azbil Corporation’s LyoQuest Arctic is a compact, eco-friendly benchtop lyophilizer using natural gases. It integrates pre-freezing, primary, and secondary drying with a plug-and-play design. Key features include an 8kg AISI 316L condenser, touchscreen vacuum control, and PLC-based process management.
  
• Moreover, the growing adoption of precision medicine, which is estimated to reach to reach USD 157.1 billion by 2032, and expansion of biopharmaceutical R&D are increasing the production volume and the complexity of the products which necessities the requirement of lyophilization devices in order to maintain the product integrate and shelf life for longer storage, thereby accelerating the demand for advanced lyophilization devices, further reinforcing the growth of the segment in the fast-pacing market of lyophilization equipment.
  

Based on scale of operation, the lyophilization equipment market is segmented into bench-top lyophilization equipment, pilot-scale lyophilization equipment, and industrial scale lyophilization equipment. The bench-top lyophilization equipment segment accounted for a 46.3% market share in 2024 and is projected for significant growth to reach USD 7.5 billion by 2034.

• The growth of the segment is owing to the adoption of bench-top lyophilization equipment among the small-scale production settings, laboratory scale pharmaceutical development, and academic research institutes.
  
• This equipment offers a cost-effective solution with user-friendly interfaces, compact design with advanced features such as precise vacuum and temperature control, making bench-top lyophilization equipment to be an ideal option for experimental and initial formulation development studies.
  
• For instance, Labconco’s FreeZone Freeze Dryers are built for research and pilot-scale labs, featuring a user-friendly touchscreen and Lyo-Works OS for real-time process control, recipe programming, and data logging. They offer benchtop and mobile models with ice capacities from 2.5 to 18 liters and temperature options of -50°C, -84°C, and -105°C.
  
• Therefore, these technological advancements of bench-top lyophilization equipment position them as a crucial tool for the efficient and controlled sample freeze drying in research and development environment, thereby boosting the segments growth.
  

Based on application, the lyophilization equipment market is segmented into autoimmune diseases, respiratory diseases, gastrointestinal disorders, oncology, cardiovascular diseases, infectious diseases, metabolic disorders, and other applications. The oncology segment accounted for a 21.7% market share in 2024 and is projected for significant growth to reach USD 2.6 billion by 2034.

• The growth of the segment is primarily stimulated by the rising prevalence of various types of cancer across the globe.
  
• For instance, as per the data from the American Cancer Society, in the U.S. it is projected that in 2025 around 316,950 women will be diagnosed from the invasive breast cancer, about 59,080 women will be diagnosed with ductal carcinoma in situ and approximately 42,170 women will die due to the breast cancer across the nation.
  
• Thus, as the diagnosis rate of breast cancer increases, so does the need for effective, stable, long acting, and targeted therapeutics in order to combat the disease.
  
• Lyophilization plays an important role in improving the stability, shelf life, and bioavailability of many such cancer therapeutics particularly injectables and biologics formulations which are predominantly sensitive to moisture and heat.
  
• Therefore, this trend is anticipated to continue, making lyophilization a crucial step in the development and production of the oncology therapeutics, fostering the segments growth in the forward direction.
  

Based on industry, the lyophilization equipment market is segmented into pharmaceutical, biotechnology, biomedical, food processing, and other industries. The pharmaceutical segment is anticipated to reach USD 3.7 billion by 2034, stimulated by the rising demand for biologics, injectable formulations, and thermal sensitive drugs which requires enhanced stability and extended shelf life.

• The lyophilization process is widely adopted in the pharmaceutical industry in order to preserve the efficacy of the formulation, to ensure sterility, and to support the long-term storage without refrigeration.
  
• Moreover, with the increasing development and regulatory approvals of complex vaccines, biologic therapies, and personalized medicines for various chronic diseases conditions, pharmaceutical companies are investing in the advanced lyophilization equipment in order to maintain the product quality and regulatory compliance during the bulk production of these therapeutics.
  
• Additionally, the rising frequency of drug shortages and the need for global distribution are reinforcing the importance of freeze-drying technologies in securing pharmaceutical supply chains.
  

The U.S. lyophilization equipment market is projected to grow significantly, reaching USD 4.7 billion by 2034.

• The growing prevalence of the cancer in the U.S. in the key catalyst for the growth of the market in the U.S.
  
• For instance, as per the data from the American Cancer Society in 2025, around 2,041,910 new cases of cancer are to be diagnosed, and 618,120 cases of cancer related deaths is projected to occur in the U.S.
  
• Thus, this rising burden of the cancer is propelling the market in the U.S. as many pharmaceutical, biotechnology companies, and research institutes are undertaking various research to develop stable and advanced therapeutical solution such as the injectables and vaccines to combat the condition. Lyophilization technologies support the development and large-scale production of advanced oncology treatments across the country, thereby propelling the market growth in the country.  
  

Europe: The lyophilization equipment market in UK is expected to experience significant and promising growth from 2025 to 2034.

• UK has a strong pharmaceutical R&D ecosystem. For instance, as per the data from the UK Parliament, the pharmaceutical industry in the UK invested around EUR 9 billion for research and development in the year 2022.
  
• Such investment stimulates the approval and development of advanced therapeutics such as vaccines, biologics, monoclonal antibodies, among others, which in turn fuels demand for lyophilization equipment in order to enhance the product stability and shelf life of the therapeutics, thereby fostering market growth in the country.
  

Asia Pacific: The lyophilization equipment market in the Japan is projected to grow significantly from 2025 to 2034.

• Japan has one of the fastest aging populations globally. For instance, as per estimates, Japan has around 36.25 million people aged 65 years and above, which leads to one-third of the entire Japanese population. The individuals of this demographic are highly prone to age related chronic diseases such cancer, cardiovascular disease, diabetes, among others, increasing the demand for advanced therapeutical options.
  
• These therapeutics often require specialized handling and preservation methods, with lyophilization (freeze-drying) playing a crucial role in ensuring product stability, extended shelf life, and ease of transportation particularly for temperature-sensitive formulations.
  

Middle East and Africa: The Saudi Arabia lyophilization equipment market is projected to grow significantly from 2025 to 2034.

• Saudi Arabia’s Vision 2030 puts a strong focus on improving healthcare and boosting local pharmaceutical production as part of its plan to diversify the economy.
  
• To support this, both the government and private sector are investing heavily in developing local facilities to produce medicines especially biologics, vaccines, and other advanced treatments. These types of drugs often need lyophilization (freeze-drying) to stay stable and last longer during storage and transport, propelling the market growth in the country.
  

Lyophilization Equipment Market Share

The market is highly fragmented with key players and new entrants constantly working to offer new products. In terms of revenue, the market share lies with the top 5 players which comprise Azbil, GEA Group Aktiengesellschaft, MechaTech Systems, Optima, and Labconco, accounting for approximately 5% of the total market share. Moreover, strategic collaboration with pharmaceutical manufacturers, research institutions, and regulatory bodies plays a critical role in advancing product development and ensuring regulatory approval. Increasing awareness of the benefits of lyophilized products, such as longer shelf life and improved stability, is encouraging adoption across sectors and enabling market players to solidify their position in this expanding industry.

Lyophilization Equipment Market Companies

Some of the eminent market participants operating in the lyophilization equipment industry include:

• ATS
• Azbil
• Buchi
• Cuddon
• GEA Group Aktiengesellschaft
• HOF Sonderanlagenbau
• IlShin BioBase
• Labconco
• MechaTech Systems
• Millrock Technology
• Optima
• W. L. Gore & Associates
• ZIRBUS technology
  
• Azbil Corporation delivers advanced automation and control solutions across sectors like manufacturing, healthcare, and infrastructure, focusing on energy efficiency, safety, and productivity. In December 2020, its subsidiary Azbil Telstar launched Lyozeta modular GMP freeze-dryers, enhancing its market presence.
  
• GEA Group Aktiengesellschaft provides innovative technology solutions across industries such as food, beverage, pharmaceuticals, and healthcare, with a strong focus on sustainability and efficiency. Operating in 62 countries, GEA offers advanced systems in separation, processing, and refrigeration through its five core business segments.
  

Lyophilization Equipment Industry News:

• In May 2024, Millrock Technology announced a strategic collaboration with LyoWave to incorporate LyoWave’s system into both existing and new freeze dryers, starting with the REVO Research and Development Freeze Dryer. This partnership enhanced Millrock’s offerings by integrating advanced freeze-drying technology, further strengthening its position in delivering innovative solutions to the pharmaceutical and biotech sectors.
  

The lyophilization equipment market research report includes an in-depth coverage of the industry with estimates and forecast in terms of revenue in USD Million from 2021 – 2034 for the following segments:

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Market, By Product

• Devices
  • Tray-style freeze dryers
  • Manifold freeze dryers      
  • Rotary freeze dryers
• Consumables
  • Lyoguard trays
  • Manifolds and vial holders/adapters
  • Vacuum pumps      
  • Product sensors and temperature probes
  • Pouches
    • Polyethylene terephthalate (PET) 
    • Polyethylene(PE)
    • Foil
  • Other consumables

Market, By Scale of Operation

• Bench-top lyophilization equipment
• Pilot-scale lyophilization equipment
• Industrial-scale lyophilization equipment

Market, By Application

• Autoimmune diseases
• Respiratory diseases
• Gastrointestinal disorders
• Oncology
• Cardiovascular diseases
• Infectious diseases
• Metabolic disorders
• Other applications

Market, By Industry

• Pharmaceutical
• Biotechnology
• Biomedical
• Food processing
• Other industries

The above information is provided for the following regions and countries:

• North America 
  • U.S.
  • Canada
• Europe 
  • Germany
  • UK
  • France
  • Spain
  • Italy
  • Netherlands
• Asia Pacific 
  • China
  • Japan
  • India
  • Australia
• Latin America 
  • Brazil
  • Mexico
  • Argentina
• Middle East and Africa 
  • South Africa
  • Saudi Arabia
  • UAE