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The biphenyl industry is witnessing increasing demand owing to the discovery of new biphenyl derivatives in the pharmaceutical industry. Recent research has highlighted the potential of biphenyl compounds in drug development. These derivatives exhibit unique biological activity, making them promising for treating various diseases such as cancer, cardiovascular disease, and neurological conditions. The antagonistic properties of some biphenyl derivatives, bacterial and fungal, have led to their use in the development of new antibiotics.
Furthermore, the versatility of biphenyl structures allows the development of drugs with improved efficacy and reduced side effects. New developments in drug delivery systems using biphenyl derivatives further enhance their therapeutic potential. This trend is fueled by ongoing research and development efforts, which continue to identify new therapeutic applications. Consequently, the market for biphenyls is expanding as pharmaceutical companies invest in these promising compounds to meet the growing demand for advanced therapies.
Citing an instance, in October 2022, ZLM-66, another promising biphenyl-containing orally active doravirine analog, was discovered. Researchers from Yanbian University, Fudan University, and Rega Medical Research Institute identified a biphenyl-substituted pyridine derivative of doravirine, an FDA-approved non-nucleoside reverse transcriptase inhibitor (NNRTI) and started developing these drugs as HIV treatments and alternative therapies.