Gene Synthesis Market - By Method (Solid-phase Synthesis), By Services (Antibody DNA Synthesis), By Application (Vaccine Development) By End-use (Academic and Research Institutes, Biopharmaceutical Companies,) & Forecast 2023 - 2032

Gene Synthesis Market Size

Gene Synthesis Market size accounted for USD 2.1 billion in 2022 and is estimated to grow at 18.7% between 2023 and 2032. Rising prevalence of genetic disorders and various chronic disease is expected to boost the market growth.
 

Rising burden of genetic disorders is expected to accelerate the adoption rate of gene synthesis and subsequent treatment, thereby augmenting the market growth. Additionally, the emergence of severe infectious disorders including COVID-19 and the Ebola pandemic has further resulted in the rising need for R&D across the globe. Hence, catering to such huge demand for newer treatment therapies, the companies are compelled to broaden their R&D capabilities with significant investments. However, rising government funding for R&D activities in the pharmaceutical industry affects is expected to propel the market revenue.
 

Gene synthesis is a laboratory technique that allows the creation of custom-made genes or DNA sequences. It involves the process of assembling nucleotides and the building blocks of DNA into a specific order to create a desired genetic sequence. This technique can be used to create completely new genes, modify existing genes, or synthesize large pieces of DNA from scratch. Further, gene synthesis comprises numerous applications in research, medicine, biotechnology, and other fields where genetic engineering is required.
 

COVID-19 Impact

The COVID-19 pandemic positively impacted the gene synthesis market share. The pandemic was noted to have disrupted the healthcare system worldwide, owing to strict lockdown and restrictions on transportation of raw materials that caused disruptions in the overall global supply chain. Also, at the initial phase of the pandemic, it was observed a slight slowdown in some non-COVID-19-related research activities that rely on gene synthesis. However, at the later stage of the year, the gene synthesis played major role for the development of COVID-19 vaccines and therapies, as well as for the production of diagnostic tests that detect the virus.
 

Furthermore, the pandemic notably highlighted the importance of synthetic biology and genetic engineering in developing new therapies and vaccines. This has spurred new innovation in the field of gene synthesis and synthetic biology, leading to the development of new techniques and tools that can be applied to other areas of research, thereby positively impacting the market trends.
 

Gene Synthesis Market Trends

Various regional and national government research agencies around the globe are recognizing the potential of gene synthesis to drive innovation and economic growth. Increasing government investment for research and development in advancing technologies such as gene synthesis and CRISPR gene editing is estimated to proliferate the market development.
 

For instance, according to Association of American Medical Colleges, in 2021, the U.S. government invested USD 1.7 billion in genome sequencing to improve the detection, monitoring, and mitigation of SARS-CoV-2 variants. Also, various market players are raising funds to advance enzymatic DNA synthesis technology. Similarly in 2021, Molecular Assemblies received USD 25.8 million funding from Casdin Capital to enhance enzymatic DNA synthesis technology.
 

Gene Synthesis Market Restraint

Lack of availability of skilled professionals may significantly hinder the market size. The rapid evolution of the technology involved in gene therapy requires greater expertise and experienced individuals for the insertion of genes and the execution of gene therapy procedures. Additionally, limited availability of training programs and degree programs that specifically focus on gene synthesis. Thus, the aforementioned factors are significantly impacting in longer lead times for gene synthesis projects, higher costs, and lower quality outcomes.
 

Gene Synthesis Market Analysis

By method, the gene synthesis market is classified into solid phase synthesis, PCR-based enzyme synthesis and chip-based synthesis. The solid phase synthesis segment accounted over 36.5% of the business share in 2022 and is projected to witness robust growth over the analysis timeframe. Solid-phase synthesis is increasingly utilised to generate canonical and modified polymers of nucleic acids, specifically DNA or RNA, making widely used technology in a variety of fields and research goals. Also, various advantages offered such as rapid generation of linear peptide intermediates, easy purification and precedent in the synthesis of large peptides among others are significantly contributing to the increasing adoption of solid phase synthesis.
 

By services, the gene synthesis market is divided into antibody DNA synthesis, viral DNA synthesis, and others. Antibody DNA synthesis segment is anticipated to grow at 18.8% throughout the forecast period. Antibody DNA synthesis is used to produce synthetic genes encoding for specific antibodies, which are then used in a variety of applications such as diagnostics, therapeutics, and research tools. Further, antibody DNA synthesis is particularly useful for developing large quantities of a specific antibody, as it allows researchers to produce a synthetic version of the gene that encodes for that antibody that be expressed in a host organism or in vitro system.
 

Based on application, the gene synthesis market is segmented into gene & cell therapy development, disease diagnosis, vaccine development and others. The gene & cell therapy development segment was valued around USD 716 million in 2022. Gene and cell therapy development is one of the most promising applications of gene synthesis and is rapidly expanding due to recent advancements in genome editing technology. Furthermore, genes that can be used to replace or modify a patient's defective or missing genes that can lead to the development of more effective and targeted therapies. Also, gene synthesis is used in the development of CAR-T cell therapies, which use genetically modified T cells to attack cancer cells, thereby propelling the market forecasts.
 

Gene synthesis market by end-use is classified as academic and research institutes, biopharmaceutical companies, contract research organizations. The academic and research institutes is projected to reach over USD 6.5 billion in 2032. Gene synthesis is becoming widely adopted in academic and research institutes owing to its numerous advantages. It enables customization that is essential for complex research studies that suffice the need of specific DNA sequences. The high accuracy of gene synthesis provides researchers with the flexibility to create complex DNA sequences that may be difficult or impossible to obtain through traditional cloning methods.
 

North America gene synthesis market accounted for over 38% revenue share in 2022 and is anticipated to grow at considerable growth rate during the forecast timeframe. This is attributed to several factors such as growing R&D investments, presence of key market players, CROs providing gene synthesis services among others is forecasted to boost the market size in North America region. Also, growing interest in synthetic biology research coupled with increasing research activities for the development of effective therapeutics will significantly proliferate the market outlook.
 

Gene Synthesis Market Share

Major market players operating in the gene synthesis market include:

• Thermo Fisher Scientifi  Inc
• Eurofins Genomics
• Brooks Automation  Inc (GENEWIZ)
• GenScript
   

These industry players majorly adopt various strategies including collaborations, acquisitions, mergers, and partnerships to create a global footprint and sustain market competition.
 

Gene Synthesis Industry News:

• In January 2023, Twist Bioscience and Astellas enter into a multitarget antibody discovery research collaboration. This strategic collaboration is aimed to discover antibodies against multiple targets of interest and curative therapies for patients suffering from diseases that lack treatment options. This strategy is predicted
• to help the company to enhance its service offerings.
   
• In April 2022, DNA Script launched new program for customers of their SYNTAX System. This allows organizations to receive early access to the latest advancements in their EDS technology. This strategy helped the company to accelerate the expansion of applications for their SYNTAX System and increasing its customer base, thereby drive revenue growth.
   

The gene synthesis market research report includes an in-depth coverage of the industry with estimates & forecast in terms of revenue in USD from 2018 to 2032, for the following segments:

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By Method

• Solid-phase Synthesis
• PCR-based Enzyme Synthesis
• Chip-based Synthesis

By Services

• Antibody DNA Synthesis
• Viral DNA Synthesis
• Others

By Application

• Gene & Cell Therapy Development
• Disease Diagnosis
• Vaccine Development
• Others

By End-use

• Academic and Research Institutes
• Biopharmaceutical Companies
• Contract Research Organizations

The above information is provided for the following regions and countries:

• North America
  • U.S.
  • Canada
• Europe
  • Germany
  • UK
  • France
  • Spain
  • Italy
  • Poland
  • Sweden
  • The Netherlands
  • Rest of Europe
• Asia Pacific
  • Japan
  • China
  • India
  • Australia
  • South Korea
  • Indonesia
  • Philippines
  • Malaysia
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Argentina
  • Columbia
  • Chile
  • Peru
  • Rest of Latin America
• Middle East & Africa
  • South Africa
  • Saudi Arabia
  • UAE
  • Israel
  • Turkey
  • Iran
  • Rest of MEA