Gene Expression Market

Gene Expression Market Size

Gene Expression Market size was valued at USD 12.5 billion in 2023 and is expected to grow at a CAGR of 7.1% between 2024 and 2032, propelled by factors such as the technological advancements and a growing emphasis on personalized medicine. Also, the growing prevalence of chronic diseases such as cancer, cardiovascular diseases, and neurological disorders contribute significantly to the growth of the market.

Altered gene expression plays a critical role in cancer development and progression. This involves activation of oncogenes and inactivation of tumor suppressor genes through various mechanisms, including genetic mutations, epigenetic modifications, and dysregulated signalling pathways. For instance, as per the Pan American Health Organization (PAHO), it is anticipated that around 20 million new cases and 10 million fatalities will arise in 2023, and annual reported cases are expected to reach about 30 million by 2040.

Gene expression is the process where information encoded in a gene is used to synthesize a functional gene product, such as a protein or RNA molecule. Further, gene expression analysis involves the measurement of the activity (expression) of genes in a biological sample to understand how different genes are turned on or off in response to various conditions. It aims to quantify the amount of mRNA produced from each gene, providing insights into the regulation and functioning of the genome.

Gene Expression Market Trends

• The growing adoption of personalized medicine is driving significant growth in the gene expression industry. Gene expression analysis plays a crucial role in personalized medicine by providing insights into the molecular mechanisms underlying diseases and helping identify specific biomarkers for diagnosis, prognosis, and treatment response prediction.

• Furthermore, as personalized medicine continues to gain traction in clinical practice, the demand for gene expression analysis tools and services is expected to grow substantially, thereby driving the expansion of the market.
  

Gene Expression Market Analysis

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Based on the process, the market is classified into sample collection, purification, cDNA synthesis & conversion, PCR analysis, and data analysis & interpretation. The data analysis & interpretation segment is set to expand at a CAGR of 7.8% through 2032.

• The segmental growth is majorly attributable to the substantial investments in research focused on cancer and the rising need for sophisticated interpretation software tailored for studies involving cancer gene expression. Diverse methodologies and algorithms are currently under development to investigate gene expression patterns in complex conditions such as cancer. For instance, techniques like projective clustering and ensemble methods are being utilized to integrate data from cancer gene expression studies effectively.

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Based on product, the gene expression market is classified into consumables, instruments, and services. Consumables segment is further sub segmented into reagents and DNA chips. Instruments are further bifurcated into polymerase chain reaction, next generation sequencing, DNA microarray and other instruments. Consumables segment accounted for 46.9% of the market share in 2023.

• Consumables encompass a range of products, including RNA extraction kits, PCR reagents, reverse transcription reagents, sequencing libraries, fluorescent dyes and probes, and other assay components essential for gene expression analysis. They are commonly utilized in gene expression experiments and are typically tailored to specific techniques or platforms. Consumables steady and regular use creates a stable market base, that supports their dominance in the market.
  

Based on application, the gene expression market is classified into drug discovery & development, clinical diagnostics, biotech & microbiology, and other applications. The drug discovery & development segment is expected to hold the highest revenue throughout the forecast period.

• Gene expression profiling have become an integral drug discovery technique for pharmaceutical companies. The effectiveness, toxicity, and other features of pharmaceuticals are assessed through monitoring the activity of a cell's genes in response to drugs.
  
• Additionally, the integration of advanced technologies, interdisciplinary collaborations, and a focus on precision medicine are projected to drive the segmental growth.
  

Based on techniques, the gene expression market is classified into RNA expression, promoter analysis, and protein expression & posttranslational modification analysis. Promoter analysis segment is predicted to witness 7.4% CAGR during 2024 to 2032.

• Promoter analysis is critical for understanding gene expression regulation and identifying significant factors that influence gene activity. It is the initial step in the computational investigation that leads to the prediction of regulatory variables.
  
• Therefore, contribution of promoter analysis in gene regulation and its growing applications in various fields including functional genomics, drug development, and disease biomarker discovery is anticipated to accelerate the market growth.
  

Based on capacity, the gene expression market is classified into low- to mid- plex and high-plex. The high-plex segment dominated around USD 8.4 billion revenue in 2023.

• It typically involves the analysis of thousands of genes, or a sizable number of gene targets. In gene expression analysis, high-plex technologies include microarrays and RNA sequencing.
  
• In addition, high-plex analysis requires less hands-on time than other standard methods like qPCR. This technique is also remarkably precise and straightforward since it eliminates the need for initial probe validation. The advancement of spatially resolved, multiplexed digital characterization systems additionally impel the segmental growth.
  

Based on end-user, the gene expression market is classified into academic and research institute, pharmaceutical and biotechnology companies, diagnostic centers, and other end-users. The academic and research institute segment is set to hold the highest revenue throughout the forecast period.

• Academic and research institutes effectively utilize gene expression analysis to advance scientific knowledge and contribute to advancements in various fields, including medicine, biotechnology, and agriculture.
  
• Further, encouraging interdisciplinary collaboration within the institute and establishing partnerships with other academic and research institutions is anticipated to accelerate the innovation and discoveries in various fields.

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North America secured a substantial market size held over USD 5.3 billion in 2023.

• The factors such as the increased funding from government agencies, private investors, and pharmaceutical companies’ fuels innovation in gene expression technologies and applications contributes significantly to the market's growth over the projection period.
  
• For instance, in August 2022, the Department of Health and Human Services issued a funding opportunity announcement (FOA) for novel research and study of structural birth defects using human translational/clinical approaches and animal models. The FOA covered several research areas, including the identification of connected modifier genes that influence the variation and vulnerability of structural birth defects gene expression, as well as the study of altered gene expression, epigenetic factors, and imprinting.
  
• Thus, aforementioned factors are anticipated to accelerate the regional market growth.
  

Gene Expression Market Share

The competitive landscape of the gene expression industry is characterized by the presence of established pharmaceutical companies vying for market share. Key players are engaging in strategic initiatives such as mergers, acquisitions, and partnerships to strengthen their product portfolios. The companies are actively adopting a multi-pronged approaches to address the rising demand for effective gene expression.

Gene Expression Market Companies

Prominent players operating in the gene expression industry are as mentioned below:

• Agilent Technologies, Inc.
• Bio-Rad Laboratories, Inc.
• F. Hoffmann-La Roche Ltd.
• GE HealthCare Technologies, Inc.
• Illumina, Inc.
• Oxford Nanopore Technologies Ltd.
• Pacific Biosciences of California, Inc.
• PerkinElmer, Inc.
• Promega Corporation
• Qiagen N.V.
• Thermo Fisher Scientific Inc.
  

Gene Expression Industry News

• In January 2023, QIAGEN Digital Insights (QDI) unveiled the QIAGEN CLC Genomics Workbench Premium, designed to tackle the bottleneck in next-generation sequencing data analysis. This advanced tool combines rapid analysis capabilities with comprehensive processing and interpretation of data from whole exome sequencing (WES), whole genome sequencing (WGS), and large panel sequencing, effectively addressing the NGS data analysis bottleneck.
  
• In September 2022, Illumina, Inc., the leading global provider of DNA sequencing and array-based technologies, introduced NovaSeq, a new line of production-scale sequencers. These advanced machines push the boundaries of what's achievable in genomic medicine by offering faster, more powerful, and environmentally sustainable sequencing capabilities. This substantial enhancement greatly accelerates genomic research and provides deeper clinical insights, ultimately advancing our understanding of diseases and potentially transforming patient outcomes.
  

The gene expression market research report includes an in-depth coverage of the industry with estimates & forecast in terms of revenue in USD Million from 2018 - 2032 for the following segments:

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Market, By Process

• Sample collection
• Purification
• cDNA synthesis & conversion
• PCR analysis
• Data analysis & interpretation

Market, By Product

• Consumables
  • Reagents
  • DNA chips 
• Instruments
  • PCR
  • NGS
  • DNA microarray
  • Other instruments
• Services

Market, By Application

• Drug discovery & development
• Clinical diagnostics
• Biotech & microbiology
• Other applications

Market, By Technique

• RNA expression
• Promoter analysis
• Protein expression & posttranslational modification analysis

Market, By Capacity

• Low- to mid- plex
• High-plex

Market, By End-user

• Pharmaceutical and biotechnology companies
• Diagnostic laboratories
• Academic research centers

The above information has been provided for the following regions and countries:

• North America
  • U.S.
  • Canada 
• Europe
  • Germany
  • UK
  • France
  • Spain
  • Italy
  • Rest of Europe
• Asia Pacific
  • Japan
  • China
  • India
  • Australia
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East and Africa
  • South Africa
  • Saudi Arabia
  • Rest of Middle East and Africa