Bone Void Fillers Market Size

Bone Void Fillers Market size was valued at around USD 3.4 billion in 2023 and is projected to observe around 6.8% CAGR from 2024 to 2032. Bone void fillers are medical devices used to fill voids or defects in bone tissue. These voids may result from trauma, surgical procedures, bone infections, degenerative diseases, or congenital conditions. The purpose of bone void fillers is to promote bone healing, regeneration, and structural support in areas where bone loss or defects have occurred.

The increasing number of orthopedic surgeries is a significant driving factor for the market. For instance, in 2023, according to the American Academy of Orthopaedic Surgeons, the number of total hip arthroplasty (THA) and total knee arthroplasty (TKA) procedures increased substantially. It is projected that there will be a 70% growth in the annual volume of primary total joint arthroplasties (TJAs) by 2050, reaching 2,257,326 orthopedic surgeries. These procedures require bone void fillers to promote bone restoration, support structural integrity, and improve patient outcomes.

Furthermore, increasing incidence of bone disorders and injuries, rising adoption of orthopedic devices (market size is estimated to account for USD 73 billion by the end of year 2032), rise in geriatric population, advancements in surgical techniques, surging bone replacement, and government initiatives and funding, are the advancing factors fostering the growth of the market.

Bone Void Fillers Market Trends

The increasing incidence of bone disorders and injuries is a significant driver for the market. Bone disorders and injuries, such as fractures, osteoporosis, degenerative bone diseases, and bone tumors, create substantial demand for these fillers to aid in bone healing and provide structural support.

• For instance, in 2023, according to the National Institutes of Health, osteoporosis causes more than 8.9 million fractures annually, resulting in an osteoporotic fracture every 3 seconds.
  
• Further, according to the report of the National Council of Aging, 1 in 2 women and 1 in 4 men over the age of 50 will break a bone due to osteoporosis in their lifetime.
  
• Bone void fillers are essential for filling voids and defects caused by traumatic injuries, providing a scaffold for new bone formation and aiding in the healing process. Fracture repair surgeries often require these fillers to stabilize and support the bone during the healing process.
  
• Both primary bone tumors (originating in the bone) and metastatic tumors (spreading to the bone from other sites) creates voids in the bone. Surgical resection of bone tumors requires the use of bone void fillers to fill the defect and stabilize the bone after tumor removal in conjunction with bone growth stimulators.
  
• Thus, as the population ages and the prevalence of chronic conditions rises, the need for effective bone void fillers is expected to continue growing, creating opportunities for innovation and expansion in the market.
  

Bone Void Fillers Market Analysis

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Based on material type, the market is divided into demineralized bone matrix, calcium sulfate, collagen matrix, tricalcium phosphate, and other material types. The demineralized bone matrix segment is estimated to account for USD 2.1 billion by 2032.

• Demineralized bone matrix (DBM) retains the natural bone structure providing an osteoconductive scaffold for new bone growth. It also contains growth factors that stimulate stem cells to differentiate into bone-forming cells (osteoinduction).
  
• According to the National Library of Medicine, in 2022, DBM was common in clinical use and accounted up to 50% of allografts used in the U.S. The collagen matrix and biologic components of DBM, particularly bone morphogenetic proteins (BMPs) are critical to its use as a bone graft and allow it to be used as a graft extender, thus leading to it greater adoption.
  
• DBM is used in various orthopedic procedures including spinal fusion, fracture repair, and joint reconstruction. It promotes the fusion of vertebrae and stabilizes the spine. Consequently, it is also used in revision surgeries where there is bone loss or non-union, providing a scaffold for bone growth.
  
• Further, the material undergoes processing to remove cellular components, reducing the risk of immune reactions or rejection.
  

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Based on form, the bone void fillers market is segmented into gel, granules, paste, putty, and other forms. The putty segment accounted for USD 1 billion in 2023.

• Putty formulations have a moldable consistency allowing surgeons to easily shape and pack the material into bone defects and irregularities. It can conform to various bone contours and shapes, ensuring optimal contact with the bone surface for effective bone regeneration.
  
• These formulations contain demineralized bone matrix (DBM), growth factors, and other bone-promoting substances. Similarly, they are available in preserved and preservative-free forms, catering to different patient needs and preferences.
  
• For instance, according to the Leader Biomedical, in 2024, the synthetic putty can be used as bone void filler in spinal surgery, orthopedic braces and support, and orthopedic surgery and is a proven an excellent alternative to human bone especially when used in with bone marrow or proline-rich proteins (PRPs).
  
• Surgeons can precisely place putty in the desired location, ensuring targeted bone regeneration and minimizing material displacement. Thus, the continued innovation and development of putty formulations are expected to maintain the segment's dominance in the market.
  

Based on application, the bone void fillers market is segmented into spine fusion, bone fracture, joint reconstruction, and other applications. The bone fracture segment held a market share of 40.5% in the year 2023.

• Bone fractures are commonly caused by accidents, falls, sports injuries, and trauma. With the aging population there is an increased incidence of fractures due to osteoporosis and age-related bone weakness.
  
• Similarly, as per National Library of Medicine, each year an estimated 1.5 million individuals suffer a fracture due to bone disease. The risk of a fracture increases with age and is greatest in women. This increasing fracture rate accelerates the adoption of bone void fillers.
  
• Fractures of long bones such as the femur, tibia, and humerus require bone void fillers for repair. In complex fractures with bone loss or fragmentation these fillers are essential for reconstruction and are used to treat non-union fractures where bone healing has not occurred naturally.
  
• Surgeons use bone void fillers in combination with internal fixation devices such as bone plate, bone screw system, and nails to alleviate fractures.
  

Based on end-use, the bone void fillers market is classified into hospitals, orthopedic clinics, ambulatory surgical centers, and other end-users. The hospitals segment held a market size of USD 1.4 billion in 2023.

• Hospitals often have specialized orthopedic departments equipped to handle a wide range of bone-related conditions and surgeries. Surgeons in these departments are experienced in using bone void fillers and understand their role in enhancing surgical outcomes.
  
• These settings offer inpatient services for orthopedic surgeries where bone void fillers are commonly used. They provide postoperative care and monitoring, ensuring proper bone healing and integration of fillers.
  
• Further, increasing number of hospitals creates a greater demand for these fillers. For instance, according to Oxford Academy, in 2023, the number of hospitals in the U.S. dedicated to bone-related care is substantial, with a total of 6,120 hospitals in the country. These hospitals play a crucial role in providing specialized care for bone fractures, osteoporosis, and other orthopedic conditions.
  
• Hospitals purchase bone void fillers in bulk taking advantage of economies of scale and negotiating lower prices. Bulk purchasing allows hospitals to reduce costs per unit making bone void fillers a cost-effective solution, thereby strengthening the growth of the market.
  

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North America bone void fillers market accounted for USD 1.4 billion revenue in 2023 and is predicted to witness substantial market growth over the analysis timeline.

• The aging population in the region leads to an increased prevalence of orthopedic conditions such as fractures, osteoporosis, and degenerative bone diseases. For instance, according to the Population Reference Bureau, the number of Americans aged 65 and older was 58 million in 2022 and is projected to reach 82 million by 2050.
  
• North America is a hub for medical device innovation with the development of advanced bone void fillers using cutting-edge technologies. Surgeons in the region often employ minimally invasive techniques where bone void fillers play a crucial role in enhancing outcomes.
  
• Robust healthcare reimbursement systems in the U.S. and Canada provide coverage for bone void fillers, making them more accessible to patients and healthcare facilities. For instance, Medicare in the U.S. covers bone void fillers for eligible patients, encouraging their use in orthopedic surgeries.
  
• The presence of multiple key players fosters competition, leading to product innovations and advancements in bone void fillers. Companies frequently launch new and improved bone void fillers, expanding the market and addressing specific surgical needs, thereby stimulating the growth of the market.
  

Bone Void Fillers Market Share

The bone void fillers industry is highly competitive, marked by several players striving for market dominance. Providers offer comprehensive bone void fillers for bone healing, maintenance, and stabilization. This includes various materials such as demineralized bone matrix and calcium sulfate that aligns with patient’s compatibility. Competition is driven by factors such as the quality and reliability of these fillers, healing properties of various forms such as gel and putty, and compliance with regulatory standards. Strategic partnerships with companies and healthcare networks play a crucial role in market positioning.

Bone Void Fillers Market Companies

Some of the eminent market participants operating in the bone void fillers industry include:

• Abyrx, Inc.
• Baxter International Inc.
• Bioventus Inc.
• BONESUPPORT HOLDING AB
• Johnson & Johnson
• Medline Industries, Inc.
• Medtronic plc
• Stryker Corporation
• Wright Medical Group N.V.
• Zimmer Biomet Holdings, Inc.
  

Bone Void Fillers Industry News:

• In March 2024, BONESUPPORT HOLDING AB, announced that the company’s 510 (k) submission for Cerament Bone Void Filler to include Spine Interbody Fusion procedure has been cleared by the FDA. This creates a way for the usages of these fillers in fusion procedure and helps to expand the product portfolio and reach of the company.
  
• In March 2024, Stryker Corporation announced that it has completed the acquisition of SERF SAS, a France-based orthopedic company. The acquisition will further strengthen the global portfolio including bone void fillers and stimulators. Thus, accelerating the sales of the company.
  

The bone void fillers market research report includes an in-depth coverage of the industry with estimates & forecast in terms of revenue in USD Million from 2021 – 2032 for the following segments:

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Market, By Material Type

• Demineralized bone matrix
• Calcium sulfate
• Collagen matrix
• Tricalcium phosphate
• Other material types

Market, By Form

• Gel
• Granules
• Paste
• Putty
• Other forms

Market, By Application

• Spine fusion
• Bone fracture
• Joint reconstruction
• Other applications

Market, By End-use

• Hospitals
• Orthopedic clinics
• Ambulatory surgical centers
• Other end-users

The above information is provided for the following regions and countries:

• North America
  • U.S.
  • Canada
• Europe
  • Germany
  • UK
  • France
  • Spain
  • Italy
  • Rest of Europe
• Asia Pacific
  • Japan
  • China
  • India
  • Australia
  • South Korea
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Argentina
  • Rest of Latin America
• Middle East and Africa
  • Saudi Arabia
  • South Africa
  • UAE
  • Rest of Middle East and Africa