Key trends are shaping the market, driven by technological advancements, evolving healthcare needs, and emerging applications.
Research and development of bispecific antibody fragments have surged, with many undergoing clinical trials for cancer and immune diseases. These fragments can simultaneously bind to two distinct antigens or epitopes, allowing for precise targeting of complex diseases, particularly in oncology. They can further guide immune cells directly to tumor cells, bolstering the immune response.
There’s a growing trend of combining antibody fragments with other therapies, such as chemotherapy and immune checkpoint inhibitors, yielding synergistic effects that enhance patient outcomes. These fragments are being integrated into immuno-oncology treatments, including checkpoint inhibitors and CAR-T therapies. Their smaller size and precision make them ideal for targeting tumor-specific antigens, further amplifying cancer treatment efficacy.
In antibody-drug conjugates, antibody fragments are paired with cytotoxic drugs for direct delivery to cancer cells. Their compact size and superior tumor penetration capabilities make them ideal for antibody-drug conjugates.
The rise in cancer biomarker research is supporting the development of antibody fragments that target specific molecular markers unique to certain cancers or autoimmune diseases, increasing treatment efficacy. Furthermore, these fragments pave the way for personalized medicine, tailoring therapies to an individual's disease profile, a crucial aspect in oncology for precision targeting.
Authors:
Mariam Faizullabhoy, Gauri Wani
Frequently Asked Questions (FAQ) :
In 2023, the market was valued at approximately USD 7.3 billion. Projections indicate a growth rate of 5.6% CAGR from 2024 to 2032.
The monoclonal antibody segment is forecasted to reach USD 7.5 billion by 2032. This dominance is due to the high specificity of monoclonal antibody fragments, which allows precise binding to specific antigens or receptors on diseased cells. This precision makes them highly effective in targeted therapies, particularly in oncology and autoimmune diseases.
The U.S. market is projected to reach USD 4 billion by 2032. The region has one of the highest cancer prevalence rates globally, with about 1.9 million new cancer cases diagnosed in 2022, driving the demand for cancer therapies and, consequently, antibody fragments.
Key players in the industry include AbbVie Inc., Amgen, AstraZeneca, BioNTech, Bristol